Benefits
- Offers a full array of protective compounds from cruciferous vegetables, including I3C, DIM, and sulforaphane
- Provides a unique blend of botanicals that improve estrogen metabolism, shifting away from carcinogenic metabolites
- Supports detoxification of a variety of environmental toxins as well as naturally produced hormones by enhancing phase 1 and phase 2 liver enzymes
- Contains botanicals with potent anti-inflammatory activity
- Suitable for vegetarians/vegans
Feature Summary
EstroVantage EM provides a comprehensive formula of plant-based compounds that improve the metabolism of estrogen and its metabolites. Cruciferous vegetables contain a variety of glucosinolates, which some studies have associated with a reduction in cancer incidence when consumed in greater amounts, most likely by causing a shift in metabolism to less carcinogenic estrogen metabolites.1,2 EstroVantage EM contains indole-3-carbinol (I3C) and its metabolite 3,3’-diindolylmethane (DIM), as well as sulforaphane from broccoli powder, all of which have been linked to lower rates of neoplastic changes and a more favourable estrogen profile.3-6 Not only do these glucosinolates improve estrogen metabolism, they also reduce inflammation by targeting key signalling molecules, such as Nrf2 and NF-κB.7,8
EstroVantage EM also includes other potent plant compounds that reduce inflammation and block carcinogenic pathways. Silymarin, a milk thistle extract, down-regulates gene products involved in the proliferation of tumour cells, along with their invasion, angiogenesis, and metastasis. In addition, it enhances glucuronidation and maintains glutathione levels.9-11 This unique combination provides green tea polyphenols, lycopene (tomato extract), turmeric and rosemary extracts, as well as calcium D-glucarate, all of which have been shown to favourably shift estrogen metabolism and reduce carcinogenic risk.12-14
Medicinal Ingredients
| Each Vegetarian Capsule Contains: | |
| Calcium D-Glucarate (d-Glucaric Acid Calcium Salt) | 75 mg |
| Indole-3-Carbinol (3-Hydroxymethylindole) | 75 mg |
| Green Tea Extract (Camellia sinensis) (leaf) (80% Catechins, 45% EGCG*, <1% Caffeine) | 50 mg |
| Tomato Extract (Lycopersicon esculentum) (fruit) (5% Lycopene) | 50 mg |
| Broccoli Powder (Brassica oleracea var. italica) (aerial) (0.36% Sulforaphane) | 27.5 mg |
| DIM (3,3’-Diindolylmethane) | 25 mg |
| Turmeric Extract (Curcuma longa) (rhizome) (95% Curcuminoids) | 25 mg |
| Milk Thistle Extract (Silybum marianum) (seed) (50–60% Silymarin) | 25 mg |
| Rosemary 6:1 Extract (Rosmarinus officinalis) (leaf) | 12.5 mg |
| * Epigallocatechin-3-gallate | |
Non-Medicinal Ingredients
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.
Dosage:
3 capsules once per day with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.
Allergens:
Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.